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KMID : 0606920070150030169
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Biomolecules & Therapeutics
2007 Volume.15 No. 3 p.169 ~ p.174
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Neuroprotective Effects of Ginkgo biloba extract, GBB, in the Transient Ischemic Rat Model
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Oh Jin-Kyung
Jung Ji-Wook
Oh Hye-Rim
Han Yong-Nam
Ryu Jong-Hoon
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Abstract
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In the present study, we investigated the neuroprotective effects of standardized Ginkgo biloba extract (GBB) (total terpene trilactones, 13 ${\pm}$ 3%; biflavone, 4.5 ${\pm}$ 1.5%; flavonol glycoside, < 8%; proanthocyanidine, under detection limit) on ischemia-reperfusion-induced brain injury in the rats. Ischemia was induced by the intraluminal occlusion of the right middle cerebral artery for 2 h and reperfusion was continued for 22 h. GBB was orally administered, promptly prior to reperfusion and 2 h after. Total infarction volume in the ipsilateral hemispheres of ischemia-reperfusion rats were significantly reduced by treatment with GBB in a dose-dependent manner (P<0.05). The therapeutic time window of GBB was 3 h in this ischemia-reperfusion rat model. Furthermore, GBB also significantly inhibited increased neutrophil infiltration of ischemic brain tissue, as estimated by myeloperoxidase activity. These findings suggest that GBB plays a crucial protective role in ischemia-induced brain injury, in part, via inhibition of neutrophil infiltration, and suggest that this GBB could serve as a neuroprotective agent following transient focal ischemic brain injury.
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KEYWORD
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Gingko biloba, Ischemia-reperfusion, Neutrophil, Myeloperoxidase
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